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AG-024322

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SI-7811

AG-024322, >98% (HPLC)

CAS No. : [837364-57-5]

IUPAC Name : N-((5-(3-(4,6-Difluoro-1H-benzo[d]imidazol-2-yl)-1H-indazol-4-yl)-4-methylpyridin-3-yl)methyl)ethanamine

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Chemical Properites
Mol. Formula :
C23H20F2N6
Mol. Weight :
418.45
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AG‑024322 potently inhibits CDK1, CDK2, and CDK4 with low‑nanomolar Ki values (1–3 nM), consistent with its profile as an ATP‑competitive pan‑CDK inhibitor. It shows broad antitumor efficacy, produces clear target engagement in vivo, and triggers apoptosis.

References : Brown A. P. et al.: Cancer Chemother Pharmacol., 62(6), 1091-101, 2008; Jessen B. A. et al.: J. Appl. Toxicol., 27(2), 133-42, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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