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AG-14361

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SL-1445

AG-14361, >98%

CAS No. : [328543-09-5]

MDL No. : MFCD18385009

IUPAC Name : 2-[4-[(Dimethylamino)methyl]phenyl]-5,6-dihydro-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one

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Chemical Properites
Mol. Formula :
C19H20N4O
Mol. Weight :
320.39
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AG-14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides.

References : Calabrese C. R. et al.: J. Natl. Cancer Inst,, 96(1), 56, 2004; Curtin N. J. et al., Clin Cancer Res., 10(3), 881, 2004; Smith L. M. et al., Clin. Cancer Res., 11(23), 8449, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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