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AG-1478

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SI-5162

AG-1478, >98% (HPLC)

CAS No. : [153436-53-4]

MDL No. : MFCD00270914

Synonyms : Tyrphostin AG-1478; NSC 693255

IUPAC Name : 6,7-Dimethoxy-4-(3'-chloroanilino)quinazoline

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Chemical Properites
Mol. Formula :
C16H14ClN3O2
Mol. Weight :
315.76
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AG-1478 is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV).

References : Bojko A. et al.: Folia Histochem Cytobiol., 50(2), 186-195, 2012;
Li W. et al.: Sci Rep., 6, 24580, 2016; Akhtar S. et al.: PLoS One 10(7), e0132215, 2015; Dorobantu C. M. et al.: Antimicrob Agents Chemother., 60(10), 6402-6, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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