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AG-1478-d6 hydrochloride

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SL-342

AG-1478-d6 hydrochloride, >98% (CP)

Isotopic Purity : 99 atom % D

MDL No. : MFCD28386061

Related CAS No. : [170449-18-0] of the unlabelled compound

Synonyms : Tyrphostin AG-1478-d6 hydrochloride; NSC-693255-d6 hydrochloride

IUPAC Name : 6,7-Dimethoxy-d6-4-(3'-chloroanilino)quinazoline hydrochloride

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Chemical Properites
Mol. Formula :
C16H8D6ClN3O2 . HCl
Mol. Weight :
358.25
Appearance :
Off-white solid
Melting Point :
258-260oC
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a deuterium labelled analog of AG-1478 hydrochloride. A selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocarditis virus (EMCV).

References : Jo M. et. al.: J. Bio. Chem., 275(12), 8806, 2000; Bojko A. et al.: Folia Histochem Cytobiol., 50(2), 186-195, 2012; Li W. et al.: Sci Rep., 6, 24580, 2016; Akhtar S. et al.: PLoS One 10(7), e0132215, 2015; Dorobantu C. M. et al.: Antimicrob Agents Chemother., 60(10), 6402-6, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term storage.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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