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AG-636

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SI-6538

AG-636, >98% (HPLC)

CAS No. : [1623416-31-8]

IUPAC Name : 1-Methyl-5-(2'-methyl-[1,1'-biphenyl]-4-yl)-1H-benzo[d][1,2,3]triazole-7-carboxylic acid

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Chemical Properites
Mol. Formula :
C21H17N3O2
Mol. Weight :
343.39
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AG‑636 inhibits DHODH with nanomolar potency (IC50 = 17 nM) and acts in a reversible, selective, and orally active manner. By disrupting pyrimidine biosynthesis, it produces strong anticancer effects across DHODH‑dependent malignancy models.

References : Gabrielle Mc Donald. et al.: Mol. Cancer Ther., 19(12), 2502-2515, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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