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AIM-100

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SI-7950

AIM-100, >98% (HPLC)

CAS No. : [873305-35-2]

IUPAC Name : (R)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine

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Chemical Properites
Mol. Formula :
C23H21N3O2
Mol. Weight :
371.44
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AIM‑100 selectively targets Ack1 with low‑nanomolar potency, inhibiting Tyr267 phosphorylation while sparing PI3‑kinase and AKT kinases. This selectivity supports its use in probing Ack1‑driven oncogenic pathways and its observed anticancer activity.

References : Mahajan K. et al.: Am. J. Pathol., 180(4), 1386-93, 2012; Mahajan K. et al.: J. Biol. Chem., 287(26), 22112-22, 2012; Mahajan K. et al.: Prostate., 70(12), 1274-85, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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