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Alisertib

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SI-4900

Alisertib, >98% (HPLC)

CAS No. : [1028486-01-2]

MDL No. : MFCD16621243

Synonyms : MLN-8237; MLN-8237

IUPAC Name : 4-((9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)-2-methoxybenzoic acid

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Chemical Properites
Mol. Formula :
C27H20ClFN4O4
Mol. Weight :
518.92
Appearance :
Off-white to Pale yellow solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Alisertib is an orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase aurora A kinase (AAK) with potential antineoplastic activity.

References : Manfredi M. G. et al.: Clin Cancer Res.,17(24), 7614-7624, 2011; Gorgun G. et al.: Blood, 115(25), 5202-521, 2010; Sehdev V. et al. Mol Cancer Ther., 11(3), 763-774, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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