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Almonertinib mesylate

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SI-7964

Almonertinib mesylate, >98% (HPLC)

CAS No. : [2134096-06-1]

Synonyms : HS-10296 mesylate

IUPAC Name : N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide methanesulfonate

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Chemical Properites
Mol. Formula :
C30H35N7O2 • CH3SO2OH
Mol. Weight :
621.76
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Almonertinib mesylate is an irreversible, orally active third‑generation EGFR inhibitor that selectively targets EGFR‑sensitizing mutations and the T790M resistance mutation. It shows sub‑nanomolar potency against T790M, T790M/L858R, and T790M/Del19 variants and reduced activity toward wild‑type EGFR, supporting its use in NSCLC research.

References : Yang H. C. J. et al.: J. Thorac. Oncol., 15(12), 1907-1918, 2020; Sullivan I. et al.: Front Med (Lausanne), 3, 76, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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