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Almorexant hydrochloride

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SI-4659

Almorexant hydrochloride, >98% (HPLC)

CAS No. : [913358-93-7]

MDL No. : MFCD27923874

Synonyms : ACT-078573 hydrochloride

IUPAC Name : (R)-2-((S)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide hydrochloride

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Chemical Properites
Mol. Formula :
C29H31F3N2O3 . HCl
Mol. Weight :
549.02
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Almorexant hydrochloride is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.

References : Malherbe P. et al.: Mol Pharmacol., 76(3), 618-631, 2009; Malherbe P. et al.: Mol Pharmacol., 78(1), 81-93,2010; Li A. et al.: J Physiol., 588 (Pt 15), 2935-2944, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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