Alsterpaullone

SI-7863

Alsterpaullone, >98% (HPLC)

CAS No. : [237430-03-4]

Synonyms : 9-Nitropaullone; NSC-705701

IUPAC Name : 9-Nitro-7,12-dihydrobenzo[2,3]azepino[4,5-b]indol-6(5H)-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : Alsterpaullone potently inhibits multiple CDKs—CDK1/cyclin B (35 nM), CDK2/cyclin A (15 nM), CDK2/cyclin E (200 nM), and CDK5/p35 (40 nM)—and strongly suppresses GSK‑3α/β activity (IC₅₀ = 4 nM). It demonstrates antitumor properties, triggers apoptosis in leukemia cells, and serves as a valuable tool for investigating neurodegenerative pathways and proliferative disease mechanisms.

References : Soni D. V. et al.: Cell Cycle, 3(3), 349-57, 2004; Lahusen T. et al.: Mol. Carcinog, 36(4), 183-94, 2003; Schultz C. et al.: J. Med. Chem., 42(15), 2909-19, 1999; Faria C. C. et al.: Oncotarget., 6(25), 21718-29, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.