AM-0466

SI-6610

AM-0466, >98% (HPLC)

CAS No. : [1642113-59-4]

IUPAC Name : 1-(3-Methoxy-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-2-oxo-N-(pyrimidin-2-yl)-1,2-dihydroquinoline-6-sulfonamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : AM‑0466 potently inhibits NaV1.7 at nanomolar concentrations and exhibits strong activity in NaV1.7‑driven histamine‑induced itch models. It also shows significant analgesic efficacy in capsaicin‑induced pain assays. Improved pharmacokinetic properties enabled its advancement into in vivo targeting and efficacy studies.

References : Russell F. Graceffa et al.: J. Med. Chem., 60(14), 5990-6017, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.