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AM-211

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SI-5186

AM-211, >98% (HPLC)

CAS No. : [175526-27-8]

IUPAC Name : 2-(2'-((3-Benzyl-1-ethylureido)methyl)-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid

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Chemical Properites
Mol. Formula :
C27H27F3N2O4
Mol. Weight :
500.52
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AM-211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively. AM-211 can be used for the potential treatment of allergic diseases.

References : Bain G. et al.: J. Pharmacol Exp Ther., 338(1), 290-301, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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