Ambrisentan impurity E

SL-5007

Ambrisentan impurity E, >98%

CAS No. : [1312092-82-2]

IUPAC Name : 2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3,3-diphenylacrylic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	125.00		Back Order	Estimated to ship on 04 October 2026
10MG	175.00		Back Order	Estimated to ship on 04 October 2026
25MG	395.00		Back Order	Estimated to ship on 04 October 2026
50MG	695.00		Back Order	Estimated to ship on 04 October 2026
100MG	1295.00		Back Order	Estimated to ship on 04 October 2026

Applications : This is an impurity of Ambrisentan (Ambrisentan impurity E), which is a highly selective antagonist of the endothelin-1 type A receptor (ETAR), used in the treatment of pulmonary arterial hypertension (PAH).

References : Weiss J. et al.: Eur J Pharmacol, 660(2-3), 298-304, 2011; Yokoyama Y. et al.: Biol Pharm Bull, 37(3), 461-465, 2014; Weiss J. et al.: Biochem Pharmacol, 85(2), 265-273, 2013; Osano A. et al.: J. Pharmacol Sci, 124(1), 86-91, 2014; Buckley M. S. et al.: Expert Opin Drug Metab Toxicol, 7(3), 371-380, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.