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Ambroxol-d5

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SL-10142

Ambroxol-d5, >98%

CAS No. : [2741380-71-0]

Synonyms : NA-872-d5

IUPAC Name : (1r,4r)-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexan-1,2,2,6,6-d5-1-ol

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Chemical Properites
Mol. Formula :
C13H13D5Br2N2O
Mol. Weight :
383.14
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a deuterium labelled version of Ambroxol . This can be used as an analytical labelled reference standard. Ambroxol is an active metabolite of the prodrug Bromhexine, exhibits significant expectorant properties. It acts as a glucocerebrosidase (GCase) chaperone, enhancing GCase activity. Additionally, Ambroxol induces pulmonary autophagy and shows potential in research related to Parkinson’s disease and neuronopathic Gaucher disease.

References : Deretic V. et al.: Expert Opin Drug Metab Toxicol., 15(3), 213-218, 2019; Migdalska-Richards A. et al.: Ann Neurol., 80(5), 766-775, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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