Ambroxol hydrochloride

SL-10143

Ambroxol hydrochloride, >98%

CAS No. : [23828-92-4]

Synonyms : NA-872 hydrochloride

IUPAC Name : 4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol hydrochloride

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Applications : Ambroxol hydrochloride is an active metabolite of the prodrug Bromhexine, exhibits significant expectorant properties. It acts as a glucocerebrosidase (GCase) chaperone, enhancing GCase activity. Additionally, Ambroxol hydrochloride induces pulmonary autophagy and shows potential in research related to Parkinson’s disease and neuronopathic Gaucher disease.

References : Deretic V. et al.: Expert Opin Drug Metab Toxicol., 15(3), 213-218, 2019; Migdalska-Richards A. et al.: Ann Neurol., 80(5), 766-775, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.