Ambroxol impurity

SL-10145

Ambroxol impurity, >98%

CAS No. : [131417-90-8]

IUPAC Name : 4-(6,8-Dibromobenzo[d][1,2,3]triazin-3(4H)-yl)cyclohexan-1-ol

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Applications : This is an impurity of Ambroxol, which is an active metabolite of the prodrug Bromhexine, exhibits significant expectorant properties. It acts as a glucocerebrosidase (GCase) chaperone, enhancing GCase activity. Additionally, Ambroxol induces pulmonary autophagy and shows potential in research related to Parkinson’s disease and neuronopathic Gaucher disease.

References : Deretic V. et al.: Expert Opin Drug Metab Toxicol., 15(3), 213-218, 2019; Migdalska-Richards A. et al.: Ann Neurol., 80(5), 766-775, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.