AMG-131

SI-6624

AMG-131, >98% (HPLC)

CAS No. : [315224-26-1]

Synonyms : INT-131

IUPAC Name : 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : AMG-131 selectively modulates PPARγ through a non‑TZD scaffold, binding in the TZD pocket but occupying a unique spatial region and contacting different residues. This distinct binding mode underlies its SPPARM activity and makes it valuable for investigating PPARγ biology in type‑2 diabetes models.

References : Linda S. Higgins et al.: PPAR Res., 2008, 936906, 2008; Alykhan Motani et al.: J. Mol. Biol., 386(5), 1301-11, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.