AMG-3969

SI-7720

AMG-3969, >98% (HPLC)

CAS No. : [1361224-53-4]

IUPAC Name : (S)-2-(4-(4-((6-Aminopyridin-3-yl)sulfonyl)-2-(prop-1-yn-1-yl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : AMG‑3969 potently disrupts the GK–GKRP interaction (IC₅₀ = 4 nM), thereby relieving GKRP‑dependent inhibition of glucokinase. It is widely used to probe hepatic glucose‑sensing and metabolic regulation.

References : Lloyd D. J. et al. Nature, 504(7480), 437-40, 2013; Nishimura N. et al.: J. Med. Chem., 57(7), 3094-116, 2014; St. Jean D. J. Jr. et al.: J. Med. Chem., 57(2), 325-38, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.