AMG-458

SI-8053

AMG-458, >98% (HPLC)

CAS No. : [913376-83-7]

IUPAC Name : 1-(2-Hydroxy-2-methylpropyl)-N-(5-((7-methoxyquinolin-4-yl)oxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : AMG‑458 is an orally active, selective c‑MET inhibitor with low‑nanomolar potency (K_i= 1.2 nM in human; 2.0 nM in mouse). Its favorable pharmacokinetic and selectivity profile makes it suitable for probing MET‑dependent signaling and tumor progression.

References : Liu L. et al.: J. Med. Chem., 51(13), 3688-91, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.