AMG-487

SI-7153

AMG-487, >98% (HPLC)

CAS No. : [473719-41-4]

IUPAC Name : (R)-N-(1-(3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(pyridin-3-ylmethyl)-2-(4-(trifluoromethoxy)phenyl)acetamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : AMG-487 is an orally active, selective CXCR3 antagonist that inhibits CXCL10 and CXCL11 binding with IC₅₀ values of 8.0 and 8.2 nM, respectively.

References : Johnson M. et al.: Bioorg. Med. Chem. Lett., 17(12), 3339-43, 2007; Walser T. C. et al.: Cancer Res., 66(15), 7701-7, 2006; Cambien B. et al.: Br. J. Cancer., 100(11), 1755-64, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.