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AMG-900

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SI-4905

AMG-900, >98% (HPLC)

CAS No. : [945595-80-2]

MDL No. : MFCD18633194

Synonyms : AMG 900

IUPAC Name : N-(4-((3-(2-Aminopyrimidin-4-yl)pyridin-2-yl)oxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine

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Chemical Properites
Mol. Formula :
C28H21N7OS
Mol. Weight :
503.58
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AMG-900 is a potent and highly selective pan-aurora kinases inhibitor with IC50 of 5 nM, 4 nM and 1 nM for aurora A, B and C, respectively.

References : Payton M. et al.: Cancer Res, 70(23), 9846-9854, 2010; Huang L. et al.: Xenobiotica, 41(5), 400-408, 2011; Geuns-Meyer S. et al.: J. Med. Chem., 58(13), 5189-5207, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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