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AMG-925 hydrochloride

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SI-7798

AMG-925 hydrochloride, >98% (HPLC)

CAS No. : [1401034-19-2]

Synonyms : FLX-925 hydrochloride

IUPAC Name : 2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethan-1-one hydrochloride

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25MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C26H29N7O2 • HCl
Mol. Weight :
508.02
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AMG-925 HCl inhibits FLT3 and CDK4 with low‑nanomolar potency (IC50= 2 ± 1 nM and 3 ± 1 nM), providing a dual‑targeted tool for probing proliferative and FLT3‑mediated oncogenic pathways.

References : Keegan K. et al.: Mol. Cancer Ther., 13(4), 880-9, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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