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Amicycline hydrochloride

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Amicycline hydrochloride, >88% (HPLC)

CAS No. : [4199-34-2]

Related CAS No. : [5874-95-3] of the free base compound.

Synonyms : 9-Aminomethyl minocycline hydrochloride; 9-Didemethyl minocycline hydrochloride

IUPAC Name : (4S,4aS,5aR,12aS)-9-Amino-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride

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Chemical Properites
Mol. Formula :
C21H23N3O7 . HCl
Mol. Weight :
465.89
Appearance :
Pale yellow solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Minocycline, which is a second generation tetracycline antibiotic with neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects.

References : Hu X. et al.: Eur. J. Pharmacol., 654(3), 274-279, 2011; Tao R. et al.: J. Cardiovasc Pharmacol., 56(6), 659-668, 2010; Padi S. S. et al.: Eur. J. Pharmacol., 601(1-3), 79-87, 2008; Brundula V. et al.: Brain 125(Pt 6), 1297-1308, 2005; Tikka T. et al.: J. Neurosci., 21(8), 2580-2588, 2001.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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