AMPK activator

SI-7979

AMPK activator, >98% (HPLC)

IUPAC Name : 2-(4-((4-Hydroxyphenethyl)amino)quinazolin-2-yl)-1H-indole-3-carbaldehyde

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This bouchardatine‑derived metabolic modulator shows nanomolar antiproliferative activity across multiple CRC cell lines, with its efficacy tightly linked to AMPK activation. Uniquely, it selectively upregulates OXPHOS, reprogramming cancer‑cell energy metabolism to suppress proliferation. It also inhibits RKO xenograft growth with clear in vivo AMPK activation, making it a promising CRC therapeutic lead and highlighting a novel anti‑CRC strategy based on AMPK activation and OXPHOS enhancement.

References : Xu Y-H. et al.: J. Med. Chem., 66(11), 7387-7404, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.