APJ receptor agonist 4

SI-6888

APJ receptor agonist 4, >98% (HPLC)

CAS No. : [2762567-70-2]

IUPAC Name : (R)-5-(3-(5-Chloro-3-fluoropyridin-2-yl)pyrrolidine-1-carbonyl)-1-(2,6-diethylphenyl)-6-hydroxy-2-(1-methyl-1H-pyrazol-3-yl)pyrimidin-4(1H)-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This activates the apelin receptor with exceptional potency (EC₅₀ = 0.06 nM; K_i= 0.07 nM) and is orally active with strong pharmacokinetic behavior in rodent heart‑failure models. Preclinical toxicology studies indicate an acceptable safety margin. The compound improves cardiac function and is widely used to explore APJ‑driven therapeutic pathways in heart‑failure research.

References :
Meng W. et al.: J. Med. Chem., 64(24), 18102-18113, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.