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Aprepitant (S,S,S)-isomer

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SL-7182

Aprepitant (S,S,S)-isomer, >98%

CAS No. : [1242175-40-1]

Synonyms : (2S,3S,1’S)-Aprepitant

IUPAC Name : 5-(((2S,3S)-2-((S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

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Chemical Properites
Mol. Formula :
C23H21F7N4O3
Mol. Weight :
534.43
Appearance :
Beige solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Aprepitant (S,S,S)-isomer is a diastereomer of Aprepitant, which is a specific NK-1R antagonist. It is used as an antiemetic agent.

References : Martinez A. N.: et al.: J. Neuroinflammation 14(1), 37, 2017; Bayati S. et al.: Eur J. Pharmacol., 791, 274-283, 2016; Mannangatti P. et al.: Psychopharmacology (Berl.) 234(4), 695-705, 2017; Barrett J. S. et al.: J. Transl Med.,14(1), 148, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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