AR antagonist

SI-7179

AR antagonist, >98% (HPLC)

IUPAC Name : 2-(1-(3-Chloro-4-cyanophenyl)-1H-pyrazol-3-yl)-N-(6-fluoropyridin-3-yl)acetamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent androgen receptor (AR) antagonist. It shows strong AR antagonistic activity (IC₅₀ up to 69 nM), overcomes antiandrogen resistance, and targets a non‑LBP AR site, likely AR binding function‑3. It demonstrates effective tumor growth inhibition in LNCaP xenografts following oral administration, supporting its promise as a novel AR antagonist scaffold for prostate cancer research.

References : Chen C. et al.: J. Med. Chem., 65(19), 13074−13093, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.