ARRY‑371797

SI-7856

ARRY‑371797, >98% (HPLC)

CAS No. : [765914-60-1]

Synonyms : ARRY-797

IUPAC Name : (S)-N-(1-Amino-4-(dimethylamino)-1-oxobutan-2-yl)-5-(2,4-difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxamide

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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : ARRY‑371797 is a potent, selective p38α inhibitor (IC₅₀ < 5 nM) that robustly inhibits LPS‑induced IL‑6 release in RPMI‑8226 cells (IC₅₀ = 0.1 nM). Its strong suppression of cytokine production highlights its utility in studies of p38α‑mediated inflammatory pathways.

References : Wright D. et al.: Blood, 108 (11), 3478, 2006; Muchir A. et al.: Hum. Mol. Genet., 21(19), 4325-33, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.