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ASK1-IN-6

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SI-6842

ASK1-IN-6, >98% (HPLC)

CAS No. : [2407451-82-3]

IUPAC Name : (S)-5-Fluoro-2-methoxy-N-(6-(4-(1,1,1-trifluoropropan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)nicotinamide

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Chemical Properites
Mol. Formula :
C17H14F4N6O2
Mol. Weight :
410.33
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : ASK1‑IN‑6 is a selective, orally active, and blood–brain barrier‑penetrant inhibitor of apoptosis signal‑regulating kinase 1 (ASK1), exhibiting high biochemical potency (IC50 = 7 nM) and strong cellular activity (IC50 = 25 nM).

References : Jones H. J. et al.: J. Med Chem., 64(20), 15402-15419, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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