AST-487

SI-5644

AST-487, >98% (HPLC)

CAS No. : [630124-46-8]

MDL No. : MFCD11983171

Synonyms : NVP-AST 487

IUPAC Name : 1-(4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : AST-487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.

References : Akeno-Stuart N. et al.: Cancer Res., 67(14), 6956-64, 2007; Weisberg E. et al.: Blood 112(13), 5161-70, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.