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AT-9283

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SI-4887

AT-9283, >98% (HPLC)

CAS No. : [896466-04-9]

MDL No. : MFCD12031513

Synonyms : AT9283

IUPAC Name : 1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea

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Chemical Properites
Mol. Formula :
C19H23N7O2
Mol. Weight :
381.43
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AT-9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays; also potent to aurora A/B, Abl(T315I).

References : Howard S. et al.: J. Med. Chem., 52(2), 379-388, 2009; Qi W. et al.: Int. J. Cancer., 130(12), 2997-3005, 2012; Santo L. et al. Clin. Cancer Res., 17(10), 3259-3271,2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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