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Atuzabrutinib

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SI-7022

Atuzabrutinib, >98% (HPLC)

CAS No. : [1581714-49-9]

Synonyms : SAR-444727; PRN-473

IUPAC Name : (R,E)-2-(3-(4-Amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile

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Chemical Properites
Mol. Formula :
C30H30FN7O2
Mol. Weight :
539.62
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Atuzabrutinib functions as a potent, selective, reversible BTK inhibitor that attenuates neutrophil recruitment through inhibition of Mac‑1 signaling. Its activity highlights its relevance in immune‑modulatory and inflammatory disease research.

References :
Herter J. M. et al.: Br. J. Pharmacol., 175(3), 429-439, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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