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Avasimibe

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SI-6559

Avasimibe, >98% (HPLC)

CAS No. : [166518-60-1]

Synonyms : CI-1011; PD-148515

IUPAC Name : 2,6-Diisopropylphenyl (2-(2,4,6-triisopropylphenyl)acetyl)sulfamate

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25MGRequest A Quote
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250MGRequest A Quote
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Chemical Properites
Mol. Formula :
C29H43NO4S
Mol. Weight :
501.73
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Avasimibe inhibits ACAT1 and ACAT2 with IC50 values of 24 µM and 9.2 µM, respectively, and is orally active. Its ability to disrupt cholesterol esterification makes it a useful tool for investigating metabolic regulation and tumor progression in prostate cancer models.

References : Taichi Ohshiro. et al.: Arterioscler. Thromb. Vasc. Biol., 31(5), 1108-15, 2011; Kangping Xiong. et al.: Cancer Cell Int., 21(1), 461, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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