AZ-084

SI-7301

AZ-084, >98% (HPLC)

CAS No. : [929300-19-6]

IUPAC Name : (5-Aminopyridin-2-yl)(9-((2,2-dimethyl-2,3-dihydrobenzofuran-4-yl)methyl)-3,9-diazaspiro[5.5]undecan-3-yl)methanone

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : AZ-084 targets CCR8 with sub‑nanomolar affinity (K_i = 0.9 nM) and acts as an orally active allosteric antagonist. By reducing Treg differentiation, it blocks pre‑metastatic niche development and lung metastasis. Its strong activity in asthma models further highlights its value in CCR8‑related disease studies.

References : Wang M. et al.: Cancer Immunol. Immunother., 71(11), 2717-2730, 2022; Connolly S. et al.: Biochem. Pharmacol., 83(6), 778-87, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.