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AZ-5576

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SI-6832

AZ-5576, >98% (HPLC)

CAS No. : [2751721-40-9]

IUPAC Name : (1S,3R)-3-Acetamido-N-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)cyclohexane-1-carboxamide

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Chemical Properites
Mol. Formula :
C21H24FN3O3
Mol. Weight :
385.44
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AZ-5576 selectively targets CDK9 with sub‑nanomolar potency (IC50 < 5 nM), leading to inhibition of RNA polymerase II Ser2 phosphorylation and transcriptional elongation. Its strong mechanistic activity supports its use in studies of hematologic cancers.

References : Bernard Barlaam, et al.; Hashiguchi T, et al.: Mol. Cancer Ther., 18(9), 1520-1532, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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