AZ-66

SI-7708

AZ-66, >98% (HPLC)

IUPAC Name : 3-(4-(4-Cyclohexylpiperazin-1-yl)pentyl)-6-fluorobenzo[d]thiazol-2(3H)-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : AZ‑66 is a potent sigma receptor antagonist, primarily targeting σ1 and σ2 receptors, and is widely used as a tool compound in neuropharmacology. It shows strong anti‑addictive, antidepressant‑like, and neuroprotective effects in preclinical models by modulating sigma‑mediated neurotransmission and neuroinflammation. AZ‑66 is frequently employed to probe sigma receptor biology, CNS signaling pathways, and the therapeutic potential of σ‑receptor blockade in neuropsychiatric disorders.

References : Robson M. J. et al.: Pharmacol Rep., 65(2), 343-9, 2013; Jamalapuram S. et al.: Biomed Chromatogr., 27(8), 1034-40, 2013; Seminerio M. J. et al.: Int. J. Neuropsychopharmacol., 16(5), 1033-44, 2013; Seminerio M. J. et al.: Eur J. Pharmacol., 691(1-3), 103-9, 2012; Seminerio M. J. et al.: AAPS J. 14(1), 43-51, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.