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AZ-960

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SI-7200

AZ-960, >98% (HPLC)

CAS No. : [905586-69-8]

IUPAC Name : (S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile

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Chemical Properites
Mol. Formula :
C18H16F2N6
Mol. Weight :
354.36
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AZ-960 selectively targets JAK2 with sub‑nanomolar affinity (Ki = 0.45 nM), providing a robust chemical probe for studying JAK2‑mediated cytokine signaling and proliferative pathways.

References : Ikezoe T. et al.: Int. J. Cancer., 129(10), 2512-21, 2011; Gozgit J. M. et al.: J. Biol. Chem., 283(47), 32334-43, 2008; Yang J. et al.: Mol. Cancer Ther., 9(12), 3386-95, 2010; Valenciano A. L. et al.: Bioorg. Med. Chem., 24(19), 4647-51, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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