AZD-1480

SI-6452

AZD-1480, >98% (HPLC)

CAS No. : [935666-88-9]

IUPAC Name : (S)-5-Chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : AZD‑1480 potently inhibits JAK1 (IC₅₀ = 1.3 nM) and JAK2 (IC₅₀ < 0.4 nM) through ATP‑competitive binding, providing strong suppression of JAK/STAT signaling in inflammation and cancer research models.

References : Derenzini E. et al.: Blood Cancer J., 1(12), e46, 2011; Scuto A. et al.: Leukemia., 25(3):538-50, 2011; McFarland B. C. et al.: Mol. Cancer Ther., 10(12), 2384-93, 2011; Xin H. et al.: Cancer Res., 71(21), 6601-10, 2011; Hedvat M. et al.: Cancer Cell., 16(6), 487-9, 2009; Ni J. et al.: Neuro. Oncol., 19(1), 22-30, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.