AZD-4625

SI-8127

AZD-4625, >98% (HPLC)

IUPAC Name : 1-((3R,14aS)-11-Chloro-9-fluoro-10-((S)-2-fluoro-6-hydroxyphenyl)-3-methyl-1,3,4,13,14,14a-hexahydro-2H-pyrazino[1',2':5,6][1,5]oxazocino[4,3,2-de]quinazolin-2-yl)prop-2-en-1-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : AZD-4625 is an orally active, selective covalent KRAS^G12C inhibitor (IC₅₀= 3 nM) that blocks MAPK and PI3K pathway signaling and promotes apoptosis. It shows strict selectivity for KRAS^G12C over wild‑type RAS and other RAS mutants, enabling focused investigation of KRAS^G12C‑dependent NSCLC biology.

References : Kettle J. G. et al.: J. Med. Chem., 65(9), 6940-6952, 2022; Chakraborty A. et al.: Mol. Cancer Ther., 21(10), 1535-1546, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.