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AZD-4747

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SI-8120

AZD-4747, >98% (HPLC)

CAS No. : [2489226-14-2]

IUPAC Name : 1-((R)-9-((S)-2-Chloro-6-hydroxyphenyl)-10-fluoro-8-(prop-1-yn-1-yl)-3,4,12,12a-tetrahydro-6H-benzo[f]pyrazino[2,1-c][1,4]oxazepin-2(1H)-yl)prop-2-en-1-one

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Chemical Properites
Mol. Formula :
C24H22ClFN2O3
Mol. Weight :
440.9
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AZD-4747 selectively targets the KRAS^G12C mutant and is capable of crossing the blood–brain barrier, making it suitable for studying KRAS‑dependent cancers, including those with CNS involvement.

References : Kettle J. G. et al.: J. Med. Chem., 66(13), 9147-9160, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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