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AZD-7687

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SI-6087

AZD-7687, >98% (HPLC)

CAS No. : [1166827-44-6]

IUPAC Name : 2-((1r,4r)-4-(4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetic acid

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Chemical Properites
Mol. Formula :
C21H25N3O3
Mol. Weight :
367.45
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AZD-7687 inhibits human DGAT1 with an IC50 of 80 nM and functions as a potent, selective, reversible, and orally active DGAT1 blocker. It is valuable for probing DGAT1‑dependent pathways in metabolic disease models, including type 2 diabetes and obesity.

References : Barlind J. G. et al. : J. Med. Chem, 55(23), 10610-29, 2012; Denison H. et al.: Diabetes Obes. Metab., 16(4), 334-43, 2014; Eike Floettmann et al.: Toxicol Pathol., 43(3), 376-83, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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