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AZD-8055

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SI-7741

AZD-8055, >98% (HPLC)

CAS No. : [1009298-09-2]

IUPAC Name : (5-(2,4-Bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol

Price And Availability
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25MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
50MGRequest A Quote
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100MGRequest A Quote
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250MGRequest A Quote
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500MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C25H31N5O4
Mol. Weight :
465.55
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AZD‑8055 potently inhibits mTOR kinase activity (IC50= 0.8 nM) in an ATP‑competitive manner and blocks signaling through both mTORC1 and mTORC2. Its oral bioavailability supports its use in mechanistic and pharmacological studies of mTOR pathway regulation.

References : Chresta C. M. et al.: Cancer Res., 70(1), 288-98, 2010; Sini P. et al.: Autophagy, 6(4), 553-4, 2010; Jiang Q. et al.: Cancer Res., 71(12), 4074-84, 2011; Willems L. et al.: Leukemia, 26(6), 1195-202, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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