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AZD-8186

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SI-3678

AZD-8186, >98% (HPLC)

CAS No. : [1627494-13-6]

MDL No. : MFCD27987908

Synonyms : AZD8186

IUPAC Name : (R)-8-(1-((3,5-Difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

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Chemical Properites
Mol. Formula :
C24H25F2N3O4
Mol. Weight :
457.47
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AZD-8186 is a potent and selective inhibitor of PI3Kβ and PI3Kδ with IC50 of 4 nM and 12 nM, respectively.

References : Barlaam B. et al.: J. Med. Chem., 58(2), 943-962,2015;Hancox U. et al.: Mol Cancer Ther., 14(1), 48-58, 2015; Marques R. B. et al.: Eur Urol., 67(6), 1177-1185, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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