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AZD-9496 maleate

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SI-5639

AZD-9496 maleate, >98% (HPLC)

CAS No. : [1639042-28-6]

MDL No. : MFCD28902196

IUPAC Name : (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid maleate

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Chemical Properites
Mol. Formula :
C25H25F3N2O2 . C4H4O4
Mol. Weight :
558.55
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AZD-9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with IC50 of 0.28 nM. AZD-9496 maleate is an orally bioavailable selective estrogen receptor degrader (SERD).

References : Weir H. M. et al.: Cancer Res., 76(11), 3307-18, 2016; De Savi C. et al.: J. Med Chem., 58(20), 8128-40, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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