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Azemiglitazone potassium

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SI-6097

Azemiglitazone potassium, >98% (HPLC)

CAS No. : [1314533-27-1]

Synonyms : MSDC-0602K

IUPAC Name : Potassium 5-(4-(2-(3-methoxyphenyl)-2-oxoethoxy)benzyl)-2,4-dioxothiazolidin-3-ide

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Chemical Properites
Mol. Formula :
C19H16KNO5S
Mol. Weight :
409.5
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Azemiglitazone potassium binds PPARγ weakly (IC50 = 18.25 µM) and functions mainly as an MPC modulator. It improves metabolic dysfunction associated with fatty liver—such as impaired lipid handling, inflammation, and insulin resistance—and enhances insulinemia and hepatic outcomes in mice, with additive benefits when paired with Liraglutide.

References : Chen Z. et al.: J. Biol Chem., 287(28), 23537-48, 2012; Colca R. J. et al.: Expert. Opin. Investig. Drugs, 27(7), 631-636, 2018; Kamm R. D. et al.: J. Biol. Chem., 296, 100807, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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