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SI-5996

B022, >98% (HPLC)

CAS No. : [1202764-53-1]

IUPAC Name : (R)-4-(1-(2-Amino-5-chloropyrimidin-4-yl)indolin-6-yl)-2-(thiazol-2-yl)but-3-yn-2-ol

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Chemical Properites
Mol. Formula :
C19H16ClN5OS
Mol. Weight :
397.88
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor. B022 protects liver from toxin-induced inflammation, oxidative stress, and injury.

References : Ren X. et al.: FASEB J. 31(2), 711-718, 2017; Li Z. et al.: J. Med. Chem., 63(8), 4388-4407, 2020; Li X. et al.: Mol Ther., 28(11), 2430-2441, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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