BACE1/2 inhibitor

SI-6484

BACE1/2 inhibitor, >98% (HPLC)

CAS No. : [2049109-19-3]

IUPAC Name : (S)-N-(3-(7-Amino-2,2-difluoro-9-(prop-1-yn-1-yl)-6-oxa-8-azaspiro[3.5]non-7-en-9-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a highly selective BACE1 inhibitor from the propynyl‑oxazine series. Achieves selectivity by displacing a high‑energy S2′ pocket water unique to BACE1, avoiding the lower‑energy water in BACE2. Delivers strong BACE1 potency, clean BACE1/BACE2 selectivity, and validates structured‑water targeting as the key design element.

References : Fujimoto K. et al.: :J. Med. Chem., 64(6), 3075-3085, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.