BACE1 inhibitor

SI-6243

BACE1 inhibitor, >98% (HPLC)

IUPAC Name : (S)-N-(3-(7-Amino-2,2-difluoro-9-(prop-1-yn-1-yl)-6-oxa-8-azaspiro[3.5]non-7-en-9-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This selective BACE1 inhibitor was discovered by targeting structured waters in the S2′ pocket. That strategy produced propynyl oxazine 3 and ultimately compound 6, a highly selective BACE1 inhibitor. Cocrystal studies show the propynyl group displaces a key S2′ water, and differences in water‑displacement energetics underpin the improved BACE1/BACE2 selectivity.

References : Fujimoto K. et al.: J. Med. Chem., 64(6), 3075-3085, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.