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Barasertib-HQPA

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SI-4885

Barasertib-HQPA, >98% (HPLC)

CAS No. : [722544-51-6]

MDL No. : MFCD10687152

Synonyms : Barasertib-hydroxyquinazoline pyrazol anilide (HQPA) ; AZD1152-HQPA; AZD-2811

IUPAC Name : 2-(3-((7-(3-(Ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-yl)amino)-1H-pyrazol-5-yl)-N-(3-fluorophenyl)acetamide

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Chemical Properites
Mol. Formula :
C26H30FN7O3
Mol. Weight :
507.56
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Barasertib-HQPA is a highly selective aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay, ~3700 fold more selective for aurora B over aurora A.

References : Yang J. et al.: Blood 110(6), 2034-2040, 2007; Wilkinson R. W. et al.: Clin Cancer Res., 13(12), 3682-3688, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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