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Bavdegalutamide

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SI-7254

Bavdegalutamide, >98% (HPLC)

CAS No. : [2222112-77-6]

Synonyms : ARV-110

IUPAC Name : N-((1r,4r)-4-(3-Chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide

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Chemical Properites
Mol. Formula :
C41H43ClFN9O6
Mol. Weight :
812.3
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Bavdegalutamide selectively targets the androgen receptor for ubiquitination and proteasomal degradation, functioning as an orally active AR‑directed PROTAC. Its mechanism supports its use in probing AR‑dependent pathways in prostate cancer research.

References : Neklesa T. et al.: American Association for Cancer Research, 78(13), 5236, 2018; Neklesa T. et al.: J. Clin. Oncol 37, 259, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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